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In this review, we have focused on several recent areas of new research: the role of ubiquitin C-terminal hydrolase L1 (Uch-L1), Ubiquitin-B+1 (UBB+1), F-box protein 2 (Fbxo2), and aggregation-promoting chaperones (CRAM-1 and MOAG-4) in Amyloid precursor protein (APP) and A related metabolism as well as the related signaling pathways in AD and SCI, and discuss pressing questions in these fields of research

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